For decades, NIAID has launched major research responses and developed medical countermeasures to combat multiple emerging infectious diseases, including HIV/AIDS, SARS-CoV-1, Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola virus, Zika virus, and SARS-CoV-2. Knowledge gained from studying prototype pathogens will also build a . Knowledge gained from studying prototype pathogens will also build a framework . Excerpt from NIAID Pandemic Preparedness Plan. As the global COVID-19 pandemic continues into its third year, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is focusing on preparing for a range of other viral threats that could cause a public health emergency. With the new NIAID Pandemic Preparedness Plan, released in December 2021 and informed by the November 2021 NIAID Workshop on Pandemic Preparedness: The Prototype Pathogen Approach To Accelerate Medical Countermeasures, the Institute directs its preparedness efforts on priority and prototype pathogens. A schematic for how prototype pathogens are selected, studied, and brought to clinical trials is shown in Figure 1. In addition, these efforts will be coordinated with similar global efforts already underway or planned so that informed worldwide surveillance and epidemiology is assured. On June 17, 2022, Member of Parliament (MP) Nathaniel Erskine-Smith tabled a private member's bill called Bill C-293, also known as the Pandemic Prevention and Preparedness Act.. NIAID seeks to accomplish the ambitious research agenda laid out in the American Pandemic Preparedness: Transforming Our Capabilities plan, the NIAID Pandemic Preparedness Plan and the Antiviral Program for Pandemics (APP), focusing on the viruses of greatest pandemic concern in 7 RNA virus families or orders: Bunyavirales, Coronaviridae . For instance, Zika virus of the Flaviviridae family is known to cause human morbidity, but it does not serve as a good prototype for development of MCMs for other Flaviviridae family members. As was recently outlined by the National Institute of Allergy and Infectious Diseases (NIAID) in their pandemic-preparedness plan (P3), research into new technologies is a cornerstone of future . The NIAID preparedness research efforts will provide the reagents, roadmaps for product development and evaluation, scientific infrastructure, and study capacity needed for a robust research response to a future pandemic. This bill includes a proposal to create an advisory committee to look at Canada's response to the COVID-19 pandemic and to require a detailed plan in order to reduce the risk of future pandemics. NIH Main Campus. Clinical Research Continuing to build a robust basic research portfolio and advancing translational science on these pathogens is essential for biomedical preparedness. The NIAID Pandemic Preparedness Plan outlines the cross-cutting epidemiology, infrastructure, technology, and coordination and communication approaches . According to NIAID's new Pandemic Preparedness Plan, the institute will direct its preparedness efforts on two fronts. CONTACT: To schedule interviews, please contact the NIAID News Office . Menu. To mitigate risks associated with these yet unknown pathogens, NIAID will prioritize preparedness research on prototype-pathogens, which are select pathogens identified from viral families known to infect humans. The emergence and re-emergence of infectious diseases continues to threaten the health of Americans and people worldwide. And there are documents such as the American Pandemic Preparedness Plan's update - the annual plan that was released in September, the one-year plan, by OSTP. The NIAID Pandemic Preparedness Plan builds on a foundation of pathogen-specific research that include advancing research on priority pathogens known to or having the potential for emerging as public health threats. NIAID, the lead NIH Institute for infectious disease research and MCM discovery, has broad capacity in infectious diseases and immunology and a history of preparing for and responding to domestic and global infectious disease threats. My IT Information. Europe PMC. NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. According to NIAIDs new Pandemic Preparedness Plan, the institute will direct its preparedness efforts on two fronts. These efforts are designed to shorten timelines between pathogen emergence and authorization/approval of candidate products. U.S. Department of Health & Human Services, NIH Institute and Center Contact Information. To ensure adequate coverage of viruses that pose a known threat to human health and Pathogen(s) X, NIAID will support both priority and prototype pathogen research through its pandemic preparedness strategy. NIAID developed a Pandemic Preparedness Plan for future public health emergencies caused by viruses. NIAID Director Anthony S. Fauci, M.D., is available to speak about the new NIAID plan. The Pandemic Preparedness Plan will support critical studies to characterize prototype and priority pathogens, including understanding viral biology and structure, host immune responses, mechanisms of immune evasion, disease pathogenesis, and studies to develop assays and animal models of disease. National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, U.S. Department of Health and Human Services. As the global COVID-19 pandemic continues into its third year, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is focusing on preparing for a range of other viral threats that could cause a public health emergency. It also will communicate and coordinate with the NIH and other relevant USG agencies as well as appropriate entities outside the U.S., including key international organizations and foreign research partners. Knowledge gained from studying prototype pathogens will also build a framework for a rapid research and product development response for other viruses within that virus family should an outbreak occur. While it is recognized that pathogens other than viruses could lead to public health emergencies, the NIAID Pandemic Preparedness Plan focuses on viruses that could cause epidemics or pandemics. NIAID Director Anthony S. Fauci, M.D., is available to speak about the new NIAID plan. WHO: NIAID Director Anthony S. Fauci, M.D., is available to speak about the new NIAID plan. The plans second key research focus is on priority pathogens viruses already known to be capable of causing significant human illness or death, such as Zika virus. Selecting representative viruses from each virus family offers a viable pathway to gain knowledge as well as develop and test candidate countermeasures that may apply to part or all of a particular virus family. 13.30 MB. The extent of preparedness will determine the speed and effectiveness of a response. The ability of NIAID to prepare for and mount a rapid and effective research response to an emerging pathogen relies on knowledgeable staff, up-to-date facilities and flexible infrastructure, cutting-edge technology, and a robust, centralized coordination hub. Technological advancements, such as platform technologies for MCMs, will also be crucial to the preparedness effort. Pandemic influenza (flu) is a rare outbreak of the influenza A virus. The Pandemic and All-Hazards Preparedness Reauthorization Act of 2013 established streamlined mechanisms to facilitate certain MCM preparedness and response activities without FDA having to issue . About Europe PMC; Preprints in Europe PMC Researchers at the University of Alabama at Birmingham Department of Pathology are hoping to continue meeting this need with a new $4.3 million scientific equipment grant from the National Institute of . NIAID will continue to collaborate with partners in the U.S. and foreign governments, the biopharmaceutical industry, and international organizations on its preparedness efforts. BARDA's Strategic Plan 2022-2026; U.S. National Pandemic Strategy; Executive Order on Modernizing Influenza Vaccines in the United States to Promote National Security and Public Health; American Pandemic Preparedness Plan Transforming Our Capabilities (September 2021) National Biodefense Strategy and Implementation Plan (October 2022); According to NIAID's new Pandemic Preparedness Plan, the institute will direct its preparedness efforts on two fronts. NIAID will focus on priority pathogens, which include pathogens that are anticipated to emerge or continue to present public health threats (e.g., influenza virus, SARS-CoV-2, Ebola virus). Thus, increasing fundamental knowledge and developing MCMs for the prototype virus(es) not only provides ready potential solutions for these viruses, but also the framework for a rapid research and product development response to other viruses within that family should an outbreak occur. Published: February 2, 2022 As the global COVID-19 pandemic continues into its third year, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is focusing on preparing for a range of other viral threats that could cause a public health emergency. Since it is not feasible to fully characterize the ~120 viruses known to cause human disease and develop MCMs for each, selection of representative viruses from each family offers a viable pathway to gain knowledge that may be applicable to part or all of a particular virus family. News releases, fact sheets and other NIAID-related materials are available on the NIAID website. Your profile picture is pulled from your NIAID Office 365 account (Skype, Teams, Outlook) and updated nightly on Inside NIAID. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For decades, NIAID has launched major research responses and developed medical countermeasures to combat multiple . According to NIAID's new Pandemic Preparedness Plan, the institute will direct its preparedness efforts on two fronts. As the global COVID-19 pandemic continues into its third year, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is focusing on preparing for a range of other viral threats that could cause a public health emergency. The new plan was informed by a November 2021 workshop NIAID hosted to facilitate discussions with the scientific community about the development of a pandemic . Research at Vaccine Research Center. Pandemic flu differs from seasonal flu and spreads quickly due to lack of immunity. NIAID will continuously engage with leadership in other federal agencies and international funders with preparedness and response capabilities to inform them on preparedness research progress. In December 2021 NIAID, building upon the successful strategies developed during the SARS-CoV-2 response and to prepare for future pandemics, published a pandemic preparedness plan that outlined a research strategy focused on priority pathogens, technology platforms, and prototype pathogens. NIAID will support the research, development, and testing of critical MCMs through Phase I/IIa clinical trials where appropriate, in coordination with other entities undertaking similar research worldwide. March 02, 2022 The plan outlines three main goals for NIAID's biomedical research portfolio: Systematically characterize pathogens of concern and increase research and surveillance to identify threats before they emerge; First, researchers will identify prototype pathogensviruses within viral families with the potential to cause significant human disease. To prepare for future public health emergencies caused by infectious diseases, NIAID has developed a Pandemic Preparedness Plan that . Prototype pathogens are representative viruses from viral groups of pandemic potential whose characterization will be used to develop MCM solutions, such as vaccines and monoclonal antibodies, applicable to itself and other emerging or re-emerging viruses in the same viral group. https://orcid.org. Knowledge gained from studying prototype pathogens will also build a . Their products will also need to be evaluated clinically through an experienced and nimble clinical trial infrastructure that complies with rigorous regulatory standards. First, researchers will identify "prototype pathogens"viruses within viral families with the potential to cause significant human disease. Download a PDF of the NIAID Pandemic Preparedness Plan, See all Pandemic Preparedness related NIAID Now posts, Read about pandemic preparedness preclinical research, Read about pandemic preparedness translational and clinical research, Read about cross-cutting pandemic preparedness efforts, Autoimmune Lymphoproliferative Syndrome (ALPS), Characterizing Food Allergy & Addressing Related Disorders, Prevention, Treatment & Control Strategies, Strategic Partnerships & Research Capacity, Primary Immune Deficiency Diseases (PIDDs), Partnership for Access to Clinical Trials (PACT), Division of Allergy, Immunology, and Transplantation, Division of Microbiology and Infectious Diseases, Dr. Joseph Kinyoun The Indispensable Forgotten Man, Dr. Joseph Kinyoun: Selected Bibliography, Diversity, Equity, Inclusion & Accessibility (DEIA) at NIAID, Intramural Scientist & Clinician Directory, Experimental Cancer Vaccine Shows Promise in Animal Studies, Monoclonal Antibody Prevents Malaria Infection in African Adults, Experimental Monoclonal Antibodies Show Promise Against Epstein-Barr Virus, How Children are Helping Scientists Battle a List of Bad Viruses, SAVENIAIDs 'Avengers-Like' Research Program for Evolving Pathogens, Systematically characterize pathogens of concern and increase research and surveillance to identify threats before they emerge, Shorten timelines between pathogen emergence or outbreak onset and authorization/approval of candidate diagnostics and medical countermeasures, such as therapeutics and vaccines, Bridge or eliminate existing gaps in research, infrastructure, and technology and expand pre-clinical and clinical testing capacity. The NIAID Pandemic Preparedness Plan builds on a foundation of pathogen-specific research that include advancing research on priority pathogens known to or having the potential for emerging as public health threats. For more information about NIH and its programs, visit www.nih.gov. NIAID aims to support critical basic and preclinical studies to characterize these prototype and priority pathogens, including understanding viral biology and structure, host-immune responses, mechanisms of immune evasion, disease pathogenesis and animal models of disease. IT Help Desk; 301-402-2502; NIAID aims to support critical basic and preclinical studies to characterize these prototype and priority pathogens, including understanding viral biology and structure, host-immune responses, mechanisms of immune evasion, disease pathogenesis and animal models of disease. The institutes comprehensive preparedness efforts will also include novel epidemiology and pathogen discovery programs, pre-clinical and clinical infrastructure capacity, technology enhancements to hasten therapeutic and vaccine development, and a robust and coordinated communication structure, according to the plan. NIAID Pandemic Preparedness Plan. Autoimmune Lymphoproliferative Syndrome (ALPS), Characterizing Food Allergy & Addressing Related Disorders, Prevention, Treatment & Control Strategies, Strategic Partnerships & Research Capacity, Primary Immune Deficiency Diseases (PIDDs), Partnership for Access to Clinical Trials (PACT), Division of Allergy, Immunology, and Transplantation, Division of Microbiology and Infectious Diseases, Dr. Joseph Kinyoun The Indispensable Forgotten Man, Dr. Joseph Kinyoun: Selected Bibliography, Diversity, Equity, Inclusion & Accessibility (DEIA) at NIAID, Intramural Scientist & Clinician Directory, Experimental Cancer Vaccine Shows Promise in Animal Studies, Monoclonal Antibody Prevents Malaria Infection in African Adults, Experimental Monoclonal Antibodies Show Promise Against Epstein-Barr Virus, Broad-spectrum protection via immunomodulation, trained immunity, and related approaches, Preclinical and clinical research infrastructure, Pilot cGMP manufacturing capacity and process development, Regulatory science and strategy infrastructure. National Institute of Allergy and Infectious Diseases (NIAID) Thus, NIAID will continue to support Zika virus research in the capacity of a priority pathogen. According to NIAID's new Pandemic Preparedness Plan, the institute will direct its preparedness efforts on two fronts. 8 While the plan is focused on pandemic preparedness, the capabilities generated will also be extremely valuable for dealing with infectious disease in general including improvements in vaccines, For example, NIAIDs earlier research on SARS-CoV-1 and MERS-CoV informed rapid vaccine development for SARS-CoV-2 in 2020. Therefore, in partnership with the CDC, USAID and other USG entities concerned with emerging infectious diseases, strategic epidemiological field studies undertaken by NIAID-supported centers and networks will provide key reagents and insights into viruses that have the potential to cause a human epidemic or pandemic. We refer to these as priority pathogens. Back to Strategic Planning, Evaluation, and Science Policy. Obtaining in-depth knowledge and developing MCMs for prototype pathogens within viral families that pose the highest risk for epidemics/pandemics is an effective strategy to prepare for future disease outbreaks. The plan focuses on four key research areas to accomplish this: Continuing to build a robust basic research portfolio and advancing translational science on these pathogens is essential for biomedical preparedness. 301-402-1663 A central NIAID team will facilitate, coordinate, and harmonize preparedness research and development within the Institute. We encourage you to take a look. Therefore, selecting representative viruses in advance from each family offers a viable pathway to gain knowledge as well as develop and test candidate countermeasures that may apply to part or all of a particular virus family. About. Knowledge gained from studying prototype pathogens will also build a framework . Given that there are approximately 120 viruses known to cause human disease, it is infeasible to fully characterize them and develop medical countermeasures (MCMs) for each. Flu causes symptoms such as fever, cough, headaches, and other body aches and sometimes complications, such as pneumonia, that can result in death. Photography: Steve Wood The COVID-19 pandemic highlighted the urgent need for new research in infectious diseases and pandemic preparedness. First, researchers will identify prototype pathogens viruses within viral families with the potential to cause significant human disease. NIAID will apply this knowledge to conduct translational and clinical research to develop diagnostics; therapeutics, including antivirals, monoclonal antibodies, and broad-spectrum approaches; and vaccines. Got It The new plan was informed by a November 2021 workshop NIAID hosted to facilitate discussions with the scientific community about the development of a pandemic preparedness strategy and prioritizing prototype pathogens within viral families of concern. NIAID also will continue to provide the USG public health infrastructure with a robust pipeline of preparedness resources to shorten the response timeline when human viral disease threats emerge. And so if COVID treatments and access can increase diagnostics and treatments for other infectious diseases, that . Preemptive approach designed to identify viral threats before they emerge. Scanning electron micrograph of Lassa virus budding off a Vero cell. WHO: Research Rules & Policies. This market research is part of the NIAID/NIH contribution to the Influenza Pandemic Preparedness Plan. Moving forward, NIAID will continue to engage the scientific community and U.S. and global partners to ensure preparedness planning efforts are collaborative, integrated, and aligned with current scientific research. Clinical trials of promising MCMs will include equitable representation of participants from traditionally underrepresented groups, all genders, and individuals across the lifespan. The plans second key research focus is on priority pathogensviruses already known to be capable of causing significant human illness or death, such as Zika virus. NIAID Annual Reports; . Continuing to build a robust basic research portfolio and advancing translational science on these pathogens is essential for biomedical preparedness. All Media Contacts, Autoimmune Lymphoproliferative Syndrome (ALPS), Characterizing Food Allergy & Addressing Related Disorders, Prevention, Treatment & Control Strategies, Strategic Partnerships & Research Capacity, Primary Immune Deficiency Diseases (PIDDs), Partnership for Access to Clinical Trials (PACT), Division of Allergy, Immunology, and Transplantation, Division of Microbiology and Infectious Diseases, Dr. Joseph Kinyoun The Indispensable Forgotten Man, Dr. Joseph Kinyoun: Selected Bibliography, Diversity, Equity, Inclusion & Accessibility (DEIA) at NIAID, Intramural Scientist & Clinician Directory, Experimental Cancer Vaccine Shows Promise in Animal Studies, Monoclonal Antibody Prevents Malaria Infection in African Adults, Experimental Monoclonal Antibodies Show Promise Against Epstein-Barr Virus, NIH Experts Call for Accelerated Research to Address Concurrent HIV and COVID-19 Pandemics, NIAID Issues New Awards to Fund Pan-Coronavirus Vaccines, Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Moderna COVID-19 Vaccine, Remdesivir Prevents MERS Coronavirus Disease in Monkeys, Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Janssen COVID-19 Vaccine. 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