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The wealth of scientific literature supports the proposal that garlic consumption have significant cardioprotective effect, which include both animal and human studies. WebDiabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level (hyperglycemia) over a prolonged period of time. Effect of aqueous extract of garlic on arterial blood pressure of normotensive and hypertensive rats. She told us: More occupational work and assessments need to be done to identify those key environmental factors that lead to these outcomes so that better prevention strategies can be developed. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and But even after taking these factors into account, people with type 2 diabetes still have an increased risk. Fruit bromelain and stem bromelainare prepared differently and they contain different enzymatic composition. Bethesda, MD 20894, Web Policies Kim-Park S, Ku DD. Until we do, well be funding and conducting research, sharing expert information, supporting patients, and spreading the word about prevention. Administration of bromelain before a surgery can reduce the average number of days for complete disappearance of pain and postsurgery inflammation [64, 65]. Keys A. Isolation and partial characterization of basic proteinases from stem bromelain. Importantly, the results analysis functionality culminates in a comprehensive and customizable report of the retrieved results. Wagner H, Wierer M, Fessler B. Jain RC. In terms of practicality, the novelty introduced by the JAII indicator is its open-accessibility to users (as opposed to a subscription service to select users). WebNobel in Chemistry to Carolyn Bertozzi, PhD. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release activity and platelet ultrastructure. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. In human studies a positive response to garlic has been observed. Occupational therapy is a branch of healthcare that focuses on helping people perform everyday activities, usually after a change in their physical or. 8600 Rockville Pike Systematically comparing this new metric to traditional journal evaluation metrics will help ensure the accuracy of JAII. J Urol. Egen-Schwind C, Eckard R, Kemper FH. Prof. Finkielstein previously worked on a study finding a protein that regulates circadian rhythms human period 2 (hPer2) may protect against cancer development through its interactions with another tumor-suppressing protein. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Arora RC, Arora S. Comparative effects of clofibrate, garlic and onion on alimentary hyperlipemia. Forschung. Learn more Adhesion molecules: a rheumatologic perspective. Bez R, Lopes MTP, Salas CE, Hernndez M. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Increased consumption of garlic is associated with lower incidence of hypertension in population. Another in vitro study showed that diallyl sulfide (oxidized product of allicin) at 5 mM significantly decreased cell viability in liver [166]. Chutani and Bordia (1981) designed one study to show that both raw and fried garlic significantly enhance FA [53]. Cooking meats at very high temperatures (frying, broiling, or grilling) creates chemicals that might raise your cancer risk. In modern era scientists have been trying to validate many of these properties of garlic, specially in terms of the identity of the active components, their mechanisms of action and exploring the potential benefits as food supplements. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. This suggests a protective effect on the elastic properties of the aorta related to aging in human [155]. Relatively few side effects were reported in clinical studies using garlic and its preparations. Shift work can lead to workers sleeping at strange or varying times of day, potentially resulting in reduced amounts of sleep. Br J Cancer. The analyses further detected that the extent of cholesterol-lowering properties of garlic differed markedly from one study to another. But another study reported that pulmonary vasodilatory effect of allicin are independent of the synthesis of NO, ATP-sensitive (K+) channel, activation of cyclooxygenase enzyme [101]. JAII is also more conducive to a comprehensive assessment of the quality and performance of journals. The concentration required for 50% inhibition of the platelet aggregation for garlic was calculated to be approximately 6.6 mg/ml plasma. In: Ruyssen R, Lauwers A, editors. WebStress is also a common factor in many other GI conditions, such as chronic heartburn (or gastroesophageal reflux disease, GERD) and irritable bowel syndrome , Winner says. The site is secure. sharing sensitive information, make sure youre on a federal At a higher concentration of bromelain, both prothrombin time (PT) and activated partial thromboplastin time (APTT) are markedly prolonged [48]. There is only one meta-analysis done by Silagy and Neil (1994) [113]. Ideally, our physiology would reset to this new condition, she said, but it might not be able to do it and the consequences of this are the onset of diseases associated with abnormal circadian rhythmicity.. Garlic inhibits free radical generation and augments antioxidant enzyme activity in vascular endothelial cells. Another widely studied garlic preparation is aged garlic extract (AGE). The symptoms of mental exhaustion can be physical, emotional, and behavioral. If you smoke and want to know more about quitting, see ourGuide to Quitting Smoking. More research is needed. Srivsatava KC. (1999) investigated the effect of allicin as an active component of garlic on the formation of fatty streaks in aorta and lipid profile in mice [21]. There is also some reported toxicity with garlic powder. Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. Direct relaxant effects of garlic juice on smooth and cardiac muscles. Blood pressure in dogs has been significantly reduced for several hours following intragastric administration of a small dose of garlic powder (as low as 2.5 mg/kg b.wt) [94]. Bromelain was also shown to inhibit bacterial endotoxin (LPS)-induced NF-B activity as well as the expression of PGE2 and Cox-2 in human monocytic leukemia and murine microglial cell lines [62, 63]. Effect of dietary garlic (. 1986. pp. When you're stressed, your body responds. Apitz-Castro R, Badimon JJ, Badimon L. Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Chung DC. Lehmann PV. This review has been made indicating an overall view of the efficacy of garlic in cardiovascular disease conditions both in human and animals. Garlic acquired a reputation in the folklore of many cultures over centuries as a formidable prophylactic and therapeutic medicinal agent. National Cancer Institute. Tochi BN, Wang Z, Xu SY, Zhang W. Therapeutic application of pineapple protease (Bromelain): a review. Kiesewetter H, Jung F, Jung EM, Mroweitz C, Koscielny J, Wenzel E. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Berger AH and Pandolfi PP. official website and that any information you provide is encrypted The gamma-glutamylcysteines are the compounds in garlic that may lower blood pressure, as indicated by their ability to inhibit angiotensin-converting enzyme in in vitro [114]. Accessed at https://www.cancer.gov/types/colorectal/patient/colorectal-prevention-pdq on February 06, 2020. and transmitted securely. Most of these cases involved an allergic contact dermatitis, sometimes severe [172], which has been reported in people with occupational exposure to garlic. Several groups of investigators [8-14] studied the effects of long term (29 months) feeding of garlic and garlic preparations (2% garlic powder in diet) on experimental atherosclerosis induced by a high-cholesterol diet in rabbits. Before Auer W, Eiber A, Hertkom E, Kohrle U, Lenz A, Mader F, Merx W, Otto G, Schmid-Oto B, benheim H. Hypertonie and Hyperlipidamie: In leichterenauch Knoblauch. African Americans have the highest colorectal cancer incidence and mortality rates of all racial groups in the US. Foushee DB, Ruffin J, Banerjee U. Garlic as a natural agent for the treatment of hypertension: A preliminary report. Imai J, Ide N, Nagae S, Moriguchi T, Matsuura H, Itakura Y. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Laurence WVD, John DF. Studies suggest that stress management techniques will not only make you feel better, but they might have concrete health benefits. In their 2011 study, X-S Wang and colleagues concluded that present and future findings should ultimately inform employment guidelines and public health interventions aimed at reducing risks among shift workers.. The Gastroenterology and Hepatology-categorized journals identified in each database are presented in Table 1 (grouped by the evaluation indicator and in descending order according to the respective quality metric value). Chronic oral administration of allicin lowered blood pressure in hypertensive rats [99,100]. New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973-2000. Chemistry and Biological Activity. Chronic feeding of garlic oil and garlic powder [78,135] showed significant decrease in blood glucose level whereas some other studies [57,117,136] showed no change of blood glucose level. Reference Citation Analysis (RCA) is a very recently launched open multidisciplinary citation analysis database based on artificial intelligence technology. Ali M, Thomson M. Consumption of garlic clove a day could be beneficial in preventing thrombosis. Smoking is a well-known cause of lung cancer, but it's linked to a lot of other cancers, too. Studies have shown that garlic has great potential in inhibiting platelet aggregation. Prolong feeding of high levels of raw garlic in rats has resulted in anemia, weight loss and failure to grow due to lysis of red blood cells [159]. The effect of fried versus Raw garlic on fibrinolytic activity in man. The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor. Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis. CS has a publication window of 3 years before the 1-year reference window and counts the references from one document type to another[20]. The observed in vivo antiplatelet effects of ingesting garlic are attributable more to adenosine than to allicin and polysulfide constituents. The authors theorized that rotating shifts made it more difficult for workers to maintain a regular sleep-wake cycle, negatively affecting sleep quality and potentially weakening insulin resistance. Moreover, there is evidence that oral therapy with bromelain produces certain analgesic and anti-inflammatory effects in patients with rheumatoid arthritis, which is one of the most common autoimmune diseases [46]. It accounts for about 2% to 4% of all colorectal cancers. In diabetes, hypertension, hypercholesterolemia etc, it is possible that disturbance in the coagulation-fibrinolytic system may be an important factor leading to the development of thrombosis and ischemia. Sheela CG, Augusti KT. The mechanism of hypotensive effect of garlic extract. Feeding of allicin (100 mg/kg/day) for 15 days in rats increased the activity of liver lipase and alpha glucal phosphorylase and decreased glucose-6-phosphatase activity [163]. The rapid recovery of platelet cyclooxygenase activity after infusion of a single dose of garlic suggests that garlic should be taken more frequently in order to achieve beneficial effects in the prevention of thrombosis [65]. Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (. Information on risk assessment, and genetic counseling and testing for these syndromes can be found in Genetic Testing, Screening, and Prevention for People with a Strong Family History of Colorectal Cancer. Federal government websites often end in .gov or .mil. Ohaeri OC. WebA risk factor is anything that raises your chance of getting a disease such as cancer. Yu-Yan Yeh, Liu L. Cholesterol lowering effect of garlic extracts and organosulfur compounds: Human and animal studies. American Cancer Society. In vitro experiments have shown that Bromelain has the ability to modulate surface adhesion molecules on T cells, macrophages, and natural killer cells and also induce the secretion of IL-1, IL-6, and tumour necrosis factor (TNF) by peripheral blood mononuclear cells (PBMCs) [3743]. For reprint requests, please see our Content Usage Policy. Ajoene, a garlic derived natural compound, present in other types of garlic oil, is an inhibitor as well as a substrate of human glutathione reductase and expected to increase the oxidative stress of the respective cell [168]. Published 2016 Mar 2. doi:10.1136/bmj.i851. HHS Vulnerability Disclosure, Help Since garlic powder is a simply dehydrated, pulverized garlic clove, the composition, especially allinase activity of garlic powder is identical to those of fresh garlic. Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. The authors are thankful to Council for Scientific & Industrial Research (CSIR), Government of India, for financial support for this work. Medication use for diabetes, hypertension, and hypercholesterolemia from19881994 to 20012006. Petkov V. Plants and hypotensive, antiatheromatous and coronarodilatating action: Zheziang Institute of Traditional Chinese Medicine The effect of essential oil of garlic on hyperlipemia and platelet aggregation an analysis of 308 cases. Data from 415 subjects were included in the analysis. Woodward PW. In: DeVita VT, Hellman S, Rosenberg SA, eds. Qureshi AA, Din ZZ, Abuirameileh N, Burger WC, Ahmed Y, Elson CE. Some studies have found that men who survive testicular cancer seem to have a higher rate of colorectal cancer and some other cancers. The evaluation of journal quality is very important for researchers. The new PMC design is here! People who have had IBD for many years, especially if untreated, often develop dysplasia. Secor ER, Jr., Singh A, Guernsey LA, et al. Imagine a world free from cancer. This could have many health benefits, including a lower risk of many kinds of cancer. Chang MLW, Johnson MA. (1) Compared with JIF and CS, JAII is able to break through the time limit disadvantage of the first two. It has been used as a medicinal plant in several native cultures [1] and these medicinal qualities of pineapple are attributed to bromelain (EC 3.4.22.32), which is a crude extract from pineapple that contains, among other compounds, various closely related proteinases, exhibiting various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities in vitro and in vivo. Garlic also inhibited endothelin-1 induced contraction in a dose-dependent manner in isolated rat pulmonary arteries [103]. Lipid management. McCrindle BW, Helden E, Conner WT. Pretreatment of rabbits with an aqueous extract of garlic (500 mg/kg) significantly inhibited thromboxane-B2 (TXB2) synthesis (a potent platelet aggregator) and protected against thrombocytopenia induced by collagen or arachidonate infusion. Therapeutic values of onion (. Several studies have suggested that men who had radiation therapy to treat prostate cancer might have a higher risk of rectal cancer because the rectum receives some radiation during treatment. Sainani GS, Desai DB, Natu MN, Katrodia KM, Valame VP, Sainani PG. Apitz-Castro R, Cabrera S, Cruz MR, Ledezma E, Jain MK. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. "Stress isn't just in your head," Winner says. Received 2012 Sep 25; Accepted 2012 Nov 13. Its also important to follow recommended screening guidelines, which can help detect certain cancers early. IBD is a condition in which the colon is inflamed over a long period of time. Studies showing no cholesterol lowering effect: Four meta-analysis of randomized, placebo-controlled human studies on hypocholesterolemic effects of garlic are available [35-38]. Bromelain can be absorbed in human intestines without degradation and without losing its biological activity [12, 13]. However, the medical and scientific communities are continually reporting that shift work can increase the risk of certain disorders and have a negative impact on the overall well-being of employees. Based on this database, Journal Article Influence Index (JAII) has been proposed as a new journal evaluation indicator. The results of the combined analysis of the three journal evaluation indicators are visualized in Figure 2A-C[18]. Pineapple cysteine endopeptidases. Ajoene strongly inhibits the metabolism of arachidonic acid by both cyclooxygenase and lipoxygenase pathways [81,82], thus inhibiting the synthesis of thromboxane A2 and 12-HETE. Although sometimes defined as "an electronic version of a printed book", some e-books exist without a printed equivalent. WebObesity is a complex disease involving an excessive amount of body fat. Bordia A, Verma SK, Srivastava KC. Allicin was identified initially as the active compound responsible for antiatherosclerotic effect. Bromelain prevents or minimizes the severity of angina pectoris and transient ischemic attack (TIA). Bromelain: an overview. When garlic is chopped or crushed, allinase enzyme, present in garlic, is activated and acts on alliin (present in intact garlic) to produce allicin. Ankylosing Spondylitis Pain: Fact or Fiction, shift workers face an increased risk of type 2 diabetes, shift work could impair the functioning of the brain, an increased risk of all-cause and cardiovascular disease mortality. In the most common type of FAP, hundreds or thousands of polyps develop in a persons colon and rectum, often starting at ages 10 to 12 years. Thus the water extract of heat-treated garlic contains mainly alliin. Accessibility 2022. In: Lawson LD & Bauer R, editor. Garlic was an important medicine to the ancient Egyptians listed in the medical text Codex Ebers (ca. Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR. Libutti SK, Saltz LB, Willett CG, and Levine RA. Bodily states affected by circadian rhythms include body temperature, wakefulness and certain hormone levels. Jamaluddin MP, Krishnan LK, Thomas A. Ajoene inhibition of platelet aggregation: possible mediation by a hemoprotein. These observations indicate that garlic may be beneficial in the prevention of thrombosis [60]. sharing sensitive information, make sure youre on a federal Most of these studies are based on men treated in the 1980s and 1990s, when radiation treatments were less precise than they are today. If you are overweight or obese (very overweight), your risk of developing and dying from colorectal cancer is higher. The removal of damaged tissue from wounds or second/third degree burns is termed as debridement. It is best not to drink alcohol. National Cancer Institute. Younger adults can get it, but it's much more common after age 50. Rashid A, Khan HH. This implies that a lot of research is required before definitive answers can be found a sentiment that Prof. Finkielstein agrees with. Besides, based on the results of RCA search by the Gastroenterology and Hepatology category, we compared JAII to JIF and CS respectively. Bromelain appears to exhibit this effect by interacting with intestinal secretory signaling pathways, including adenosine 3:5-cyclic monophosphatase, guanosine 3:5-cyclic monophosphatase, and calcium-dependent signaling cascades [51]. Pineapple is the leading edible member of the family Bromeliaceae, grown in several tropical and subtropical countries including Philippines, Thailand, Indonesia, Malaysia, Kenya, India, and China. Tax ID Number: 13-1788491. Physician Data Query (PDQ). WebAn ebook (short for electronic book), also known as an e-book or eBook, is a book publication made available in digital form, consisting of text, images, or both, readable on the flat-panel display of computers or other electronic devices. Decreased plasma viscosity and increased (55%) capillary skin perfusion were observed even after 5 hours of garlic powder administration [157]. Maximum inhibition of TXB2 occurred between 0.5 h and 6 h at 25 and 100 mg/kg garlic. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. Received 2002 Oct 10; Accepted 2002 Nov 19. garlic, animal experiment, clinical trial, cardiovascular, {"type":"entrez-nucleotide","attrs":{"text":"A23187","term_id":"833253","term_text":"A23187"}}. Journal ISSN : 2165-7386; Journal h-index : 14 ; Journal cite score : 9.29 ; Average Acceptance to publication time (5-7 days) Average Article processing time Less than 5 volumes 30 days 8 - 9 volumes 40 days These genes normally help repair DNA that has been damaged. Toxicity tests on dogs, with increasing level of bromelain up to 750mg/kg administered daily, showed no toxic effects after six months. If you have a family history of adenomatous polyps or colorectal cancer, talk with your doctor about the possible need to start screening before age 45. In recent decades, the different journal categories have been subjected to many holistic analyses. CA: A Cancer Journal for Clinicians. Jain RC. Effect of allicin on certain enzymes of liver after a short term feeding to normal rats. A pilot study of garlic consumption shows no significant effect on markers of oxidation or sub-fraction composition of low-density lipoprotein including lipoprotein(a) after allowance for non-compliance and the placebo effect. Onion, garlic, and experimental atherosclerosis. Making Strides Against Breast Cancer Walks, Genetic Testing, Screening, and Prevention for People with a Strong Family History of Colorectal Cancer, Regular moderate to vigorous physical activity. Jay Winner, MD, author, Take the Stress out of Your Life; founder and director, Stress Management Program, Sansum Clinic, Santa Barbara, Calif. Blumenthal, J. Archives of Internal Medicine, October 1997. In one study related to bromelain treatment of gastric carcinoma Kato III cell lines, significant reduction of cell growth was observed [55] while in another study bromelain reduced the invasive capacity of glioblastoma cells and reduced de novo protein synthesis [56]. In addition, the JIF and CS of high-quality journals may be more susceptible to this effect, and their fluctuations can be effectively explained. Abnormalities in the metabolism of carbohydrate, protein, and fat are also present [122]. Bromelain applied as a cream (35% bromelain in a lipid base) can be beneficial for debridement of necrotic tissue and acceleration of healing. 2011;104(7):12021206. Evidence for the mechanism by which these oils inhibit platelet aggregation. Like enhancement of fibrinolysis, garlic also has a beneficial effect on platelet adhesion or aggregation in human (Table- (Table-3).3). Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic. In-thermal burns. Bordia A, Verma SK, Vyas AK, Khabya BL, Rathore AS, Bhu N, Bedi HK. Yoshioka K Izutsa S, Asa Y, Takeda Y. Inactivation kineticsof enzyme pharmaceuticals in aqueous solutions. The medicinal value of garlic is best known for its lipid lowering and antiatherogenic effects. Mynott TL, Ladhams A, Scarmato P, Engwerda CR. There have also been sporadic reports of allergic conjunctivitis, rhinitis, or bronchospasms occurring in response to garlic inhalation or ingestion [173,174]. L-Pyroglutamyl-L-phenylalanyl-L-leucine-p-nitroanilide: a chromogenic substrate for thiol proteinase assay. It is also quite interesting that the garlic-specific increase in walking distance did not appear to occur until the 5th week of treatment [87]. Lewin G, Popov I. Antioxidant effects of aqueous garlic extract. SKM participated in its design, coordination and drafting the manuscript. Experiment in mice showed that antacids such as sodium bicarbonate preserve the proteolytic activity of bromelain in the gastrointestinal tract [10]. This fact places great importance on circadian rhythms, but what precisely are they? A similar principle is applied to evaluation of the journals that publish these scientific articles[2]. The process yields a yellowish powder, the enzyme activity of which is determined with different substrates such as casein (FIP unit), gelatin (gelatin digestion units), or chromogenic tripeptides [7, 17, 19, 20]. A meta-analysis of randomized clinical trials. Biochemical Properties. Several studies have been carried out indicating that bromelain has useful phytomedical application. This database covers a wide array of seemingly disparate disciplines such as business, economics and management, chemistry and materials science, engineering and computer science, health and medical sciences, humanities, literature and arts, life sciences and earth sciences, physics and mathematics, and social sciences. Mondal S, Bhattacharya S, Pandey JN, Biswas M. Evaluation of acute anti-inflametry effect of Ananas Comosus leaf extract in Rats. and transmitted securely. The journals listed in the JCR are further subgrouped by the ranking of JIF-related indicators (i.e. 2003;348:919932. And some people who get the disease may not have any known risk factors. We have a look at why this could be and what can be done about it. FAP is caused by changes (mutations) in the APC gene that a person inherits from parents. Others, like a persons age or family history, cant be changed. Geng Z, Lau B. Molecular basis by which garlic suppresses atherosclerosis. Med Phys. Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. In two different enzymatic debridement studies carried out in porcine model, using different bromelain-based agents, namely, Debriding Gel Dressing (DGD) and Debrase Gel Dressing showed rapid removal of the necrotic layer of the dermis with preservation of the unburned tissues [68, 69]. Symptoms. Presumably, the anticancerous activity of bromelain is due to its direct impact on cancer cells and their microenvironment, as well as on the modulation of immune, inflammatory, and haemostatic systems [12]. Makheja AN, Bailey JM. Tassman GC, Zafran JN, Zayon GM. Those with a cycle length of about 1 day are called circadian rhythms.. UpToDate. The site is secure. Bhui K, Prasad S, George J, Shukla Y. Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway. For comparisons between JAII and 2021 JIF/2021 CS, we conducted statistical analyses and provided an intuitive method for visual representation of the related data. The crude aqueous extract from stem and fruit of pineapple is known as bromelain. Try to stay on the same sleep schedule every day of the week, even on days off, to help align the body clock with the work schedule. Most of the in vitro and in vivo studies on anticancer activity of bromelain are concentrated on mouse and human cells, both cancerous and normal, treated with bromelain preparations. Bethesda, MD 20894, Web Policies Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study. Tongia SK. These include the lack of statistical timeliness, a feature by which JAII is slightly inferior to JIF and CS, and the lack of consideration to different developments of the same journal in different periods. The IF of a T-year journal is defined as the number of times that the journal has been cited in years T-1 and T-2 divided by the number of documents that can be cited in the journal in years T-1 and T-2[19]. Bromelain is absorbed from the gastrointestinal tract in a functionally intact form; approximately 40% of labeled bromelain is absorbed from intestine in high molecular form [21]. Effect of the active principle of garlic-diallyl sulfide- on cell viability, detoxification capability and the antioxidation system on primary rat hepatocytes. People with Lynch syndrome can have polyps, but they tend to only have a few. Waltham, MA: UpToDate Inc. https://www.uptodate.com (Accessed on February 05, 2020.). Core Tip: Compared with Journal Impact Factor (JIF) and CiteScore (CS), the newly-launched Journal Article Influence Index (JAII) breaks through the time limit feature of the former indexes. While CS may be more balanced and most certainly is more transparent[13], it also shares some key limitations with the JIF[14,15]. When Dolly Parton sang of working 9 to 5, she expressed concern for people barely getting by with a hard life of routine that only seems to benefit the boss. Colorectal Cancer Prevention. Garlic elicits nitric-oxide-dependent relaxation in pulmonary arteries. The studies of Jamaluddin et al (1988) demonstrated that ajoene interacts with a purified hemoprotein implicated in platelet activation [84]. Chapter 74 Colorectal Cancer. A pilot study. A combination of bromelain and other nutrients protect against ischemia/reperfusion injury in skeletal muscle [23]. Almost all human studies on fibrinolytic activity of garlic have been found to have positive effect (Table- (Table-2).2). Nowadays, bromelain is used for treating acute inflammation and sports injuries [31]. A combination of bromelain, trypsin, and rutin was compared to diclofenac in 103 patients with osteoarthritis of the knee. The long-term use of garlic in ischemic heart disease. Studies with a dried garlic powder (Kwai tablets) showed an average decrease in blood pressure of about 9% with 0.6 g garlic powder per day [77,109] and in a randomized double blind trial, a beneficial effect of garlic on blood pressure and blood lipids in mildly hypertensive subjects was demonstrated [110]. These long-standing efforts have led to researchers proposing various methods that improve the assessment of the quality of scientific journals[3,4]. Medicinally used garlic oil is mostly prepared by steam-distillation process. American Cancer Society. Samson RR. This review has attempted to make a bridge the gap between experimental and clinical study and to discuss the possible mechanisms of such therapeutic actions of garlic. Analysis of hypotensive action of, Pantoja CV, Chiang Ch L, Norris BC, Concha JB. WebJournal Impact Factor Report 2020-2021 - List of journals evaluated for impact factor, anakkale Onsekiz Mart University Journal of Graduate School of Natural and Applied Sciences; ISSN - / EISSN 2459-1580; Sylem Journal of Philology; ISSN - / EISSN 2548-0502; Journal of Digestive Disorders and Diagnosis; Kumar GR, Reddy KP. Bromelain was found to downregulate NF-B and Cox-2 expression in mouse papillomas [54] and in models of skin tumourigenesis [61]. In 1975, Bordia first demonstrated that garlic oil increased FA after 3 hours of administration. However, these results are yet to be amalgamated and critically compared so as to make out whether bromelain will gain wide acceptance as a phytomedical supplement [8]. doi:10.3322/caac.21591. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). Learn more about treating those symptoms and when to get help from a. In ancient Chinese medicine, garlic was prescribed to aid respiration and digestion, most importantly diarrhea and worm infestation [3]. Studies have found many health problems related to stress. PMC legacy view Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis. Checklist of Responsibilities for the Scientific Editor of This Article. Most of these studies showed significant decrease in serum cholesterol and serum triglyceride. However, there are numerous things that can disrupt peoples circadian rhythms and cause them problems. Betz E, Weidler R. Die Wirkung von Knoblauchextrakt auf die atheerogenese bei kaninchen. In most cases, this disorder is caused by an inherited defect in either the MLH1, MSH2 or MSH6 gene, but changes in other genes can also cause Lynch syndrome. Most of these studies reported a statistically significant reduction in atheromatous lesions, particularly in the aorta, that averaged about 50%. Life style modification are definitive therapy for some and adjunctive therapy for all persons with hypertension (Joint National Committee, 1997). Maurer HR. Other cancers linked with Lynch syndrome include cancer of the ovary, stomach, small intestine, pancreas, kidney, prostate, breast, ureters (tubes that carry urine from the kidneys to the bladder), and bile duct. Allicin also caused pulmonary vasodilatation in isolated lung of rat [101]. It's a built-in physiologic response to a threat. To evaluate and summarize the similarities and differences between JAII and JIF/CS as journal evaluation indicators, and provide an intuitive method for visual representation of the related data. It is proved that bromelain is well absorbed in body after oral administration and it has no major side effects, even after prolonged use. Effect of bromelain of fibrinogen level, protrombin complex and platelet aggregation in the rat-a preliminary report. The duration of these studies was at least 4 weeks. Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. [13] bromelain was detected to retain its proteolytic activity in plasma and was also found linked with alpha 2-macroglobulin and alpha1-antichymotrypsin, the two antiproteinases of blood. Only one study showed that aqueous garlic extract increased the amplitudes of atrial complex 'p' wave and the ventricular complex 'QRS' of the rat ECG. JAII: JAIIs, calculated as total citations divided by total articles, are based on journals and their citations included in the RCA database. Farva D, Goji LA, Joseph PK, Augusti KT. el-Sabban F, Fahim MA, Radwan GM, Zaghloul SS, Singh S. Garlic preserves patency and delays hyperthermia-induced thrombosis in pial microcirculation. Colorectal cancer: Epidemiology, risk factors, and protective factors. New Malignancies Following Cancer of the Male Genital Tract. Siegreist, J. European Archives of Psychiatry & Clinical Neuroscience, 2008: vol 258, Supplement 5: pp 115119.. Read here about the link between air pollution and mortality that a major study found. Ali M, Bordia T, Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. Hu W, Wang AM, Wu SY, et al. For more on Lynch syndrome, see What Causes Colorectal Cancer?, Can Colorectal Cancer Be Prevented?, and Family Cancer Syndromes. Dosages of 1500mg/kg per day when administered to rats showed no carcinogenic or teratogenic effects and did not provoke any alteration in food intake, histology of heart, growth, spleen, kidney, or hematological parameters [76]. Ariga T, Oshiba S, Tamada T. Platelet aggregation inhibitor in garlic. Total lipid content and cholesterol levels in liver were also decreased in rat after chronic garlic consumption. This figure is supported by a poll conducted by the National Sleep Foundation (NSF) in 2005, which found 14% of Americans work shifts. De-Guili M, Pirotta F. Bromelain: interaction with some protease inhibitors and rabbit specific antiserum. Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a treatment for osteoarthritis: a review of clinical studies. The cancers linked to this syndrome tend to develop when people are relatively young. Research. Circadian clocks and the SCN can also be influenced by factors such as exercise, hormones and forms of medication. In addition to these advantages, JAII has a high degree of compliance with JIF and CS in the evaluation of journals with a lower impact. The crude aqueous extract from stem and fruit of pineapple is known as bromelain. Oil-macerated garlic oil contains the vinyl-dithiins and ajoenes. Protective effect of garlic oil on the changes produced by 3 weeks of fatty diet on serum cholesterol serum triglycerides, fibrimolytic acativity and platelet adhesiveness in man. Dysplasia is a term used to describe cells in the lining of the colon or rectum that look abnormal, but are not cancer cells. Women with this condition also have a very high risk of developing cancer of the endometrium (lining of the uterus). 2018;33(9):1149-1158. doi:10.1007/s00384-018-3114-7. Houck JC, Chang CM, Klein G. Isolation of an effective debriding agent from the stems of pineapple plants. People that work shifts can experience similar problems to jet lag. Augusti KT, Sheela CG. Chen L, Hong JY, So E, Hussain AH, Cheng WF. Figure 2A gives a comparison of the values between the three evaluation indicators of the same journal (73 in total, taking the intersection). Papantoniou K, Devore EE, Massa J, et al. Garlic causes direct antiatherogenic (preventive) and antiatherosclerotic (causing regression) effects at the level of artery wall [39]. Patient with hyperlipidemia who received garlic supplements. Warshafsky and his colleagues deduced from five randomized clinical trials that hypercholesterolemic patients treated with garlic had a mean plasma cholesterol concentration, that was 9% lower than that of patients treated with placebo [36]. Li JY, Yan ZH, Xiang Z, Gao C, Wu J. Metabolism of garlic constituents in the isolated perfused rat liver. Besides subjective improvement, the results of these studies indicated a moderate hypotensive effect involving a drop in SBP of 2030 mm Hg and in DBP of 1020 mm Hg. Its activity varies greatly with different preparations [67]. Proceedings of the 3rd International Conference on Biotechnology for the Wellness Industry; 2010; PWTC; Neumayer C, Fgl A, Nanobashvili J, et al. Garlic extract containing diallyl disulfide and diallyl trisulfide, prevented acute platelet thrombus formation in stenosed canine coronary arteries [64]. Sheela CG, Kumud K, Augusti KT. Bethesda, MD, 2006. The next time you feel stressed, here are four stress relief tips you can try. And (3), compared with JIF and CS, JAII is more conducive to high-quality journal evaluation. HHS Vulnerability Disclosure, Help Bromelain is found to increase the expression of p53 and Bax in mouse skin, the well-known activators of apoptosis [54]. Shouldnt Ms. Parton be just as concerned about their welfare? Kaye AD, De Witt BJ, Anwar M, Smith DE, Feng CJ, Kadowitz PJ, Nossaman BD. 2. All human studies (Table- (Table-5),5), except one or two, showing effect of garlic on blood glucose level on normal healthy individuals but not in diabetic patients. 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